Experts Baffled by the Impact of CBD in Weed on Huntington’s Disease – Learn More
Jul
Approximately 1 in 7,000 people in Canada have Huntington’s disease, and 1 in 5,500 is at risk of inheriting the disease. Even with limited research, the discovery of CBD’s potential benefits for Huntington’s Disease has sparked curiosity and a search for more information.
As you explore CBD’s impact on Huntington’s Disease, consider the convenience and accessibility when you buy weed online. This blog will show you how your favorite cannabis products could potentially help with diseases like HD.
Key Takeaways:
- Abnormal involuntary movements, loss of muscle control, and cognitive decline characterize Huntington’s disease.
- Cannabidiol (CBD) has potential therapeutic effects on Huntington’s Disease.
- There is a need for abundant research on CBD’s impact on Huntington’s disease.
Overview of Huntington’s Disease
Huntington’s disease (HD), also known as Huntington’s chorea due to abnormal twisting and writhing movements, affects the brain and nervous system. This leads to loss of muscle control and dementia.
At the age of eight, George Huntington, an American physician, first saw patients with the disease that would later bear his name while accompanying his father and grandfather on medical rounds. When he turned 21 in 1872, he accurately and succinctly described the disease, which led to it being named after him.
Types of Huntington’s Disease:
- Adult Onset. This form is the most prevalent. Symptoms commonly manifest in individuals during their mid-30s and 40s.
- Early Onset (Juvenile Huntington’s Disease). Children affected by this variation commonly face sudden challenges with schoolwork and commonly exhibit symptoms akin to those of Parkinson’s disease.
Cause and Symptoms
| Cause | Symptoms |
| Inherited genetic mutation in the HTT (Huntingtin) gene, characterized by an expansion of CAG repeats. | Uncontrolled movements, loss of coordination, difficulty swallowing (dysphagia), slurred speech, emotional changes, problems with memory, focus, multitasking, and difficulty making decisions and reasoning. |
Treatment options for Huntington’s disease include:
- Medications. Tetrabenazine (Xenazine) and deutetrabenazine (Austedo) are prescribed to alleviate involuntary movements.
- Speech Therapy. This therapy enhances speech, swallowing, and eating abilities, reducing related challenges.
- Physical and Occupational Therapy: These therapies enhance muscle strength, flexibility, and balance. Therapists can tailor exercise plans to suit the individual’s changing physical condition.
Cannabidoil for Huntington’s Disease
Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis, a plant with a rich history as a medicine going back thousands of years. It is a safe, non-addictive substance, one of more than a hundred phytocannabinoids, which are unique to cannabis and give the plant its potent therapeutic profile.
How CBD Works
CBD activates or blocks cannabinoid receptors CB1 and CB2. These receptors regulate sleep, mood, and appetite as part of the endocannabinoid system (ECS). CBD may also interact with certain serotonin or opioid receptors and stimulate a process that decreases cholesterol and blood sugar levels.
CBD has demonstrated neuroprotective effects in preclinical and clinical studies. It offers potential treatments for epilepsy, multiple sclerosis (MS), Parkinson’s disease (PD), Alzheimer’s disease (AD), and other nervous system disorders. Researchers have extensively studied CBD’s role in neurodegenerative diseases and their underlying mechanisms.
Cannabis as a Promising Solution for Huntington’s Disease
A study from one of the universities in Spain shows a guarantee in how CBD slows disease progression in neurodegenerative disorders like HD. Experts focused on the antioxidant properties and CB2 receptor activation capabilities of CBD.
Methods
The study examined experimental models to understand how cannabinoids such as Δ9-tetrahydrocannabinol and cannabidiol protect neurons in the brain’s nigral or striatal regions. The study also investigates the role of CB1 and CB2 receptors in these mechanisms.
Findings
- They protect brain neurons from oxidative damage and reduce toxicity by activating CB2 receptors.
- The up-regulation of CB2 receptors in response to damage suggests the body’s natural neuroprotective mechanism.
- CB2 receptor agonists are promising PD and HD therapeutic agents, affirming additional clinical evaluation.
What Other Scholars Say About CBD on HD
Another study from the Universidad Complutense in Spain revealed that CBD has neuroprotective effects against 3NP-induced striatal damage. The study explores CBD’s antioxidant properties and its preferential action on specific neuronal pathways in the brain. It also investigates CBD’s independence from certain receptors.
Methods
The study tested if cannabinoids could protect rats with brain damage caused by 3-nitropropionic acid (3NP), a chemical that affects mitochondria. They used three cannabinoids: ACEA, HU-308, and CBD.
Results
3NP lowered GABA levels and markers for certain brain cells. It also reduces natural antioxidants. CBD reversed these effects, especially on cells connecting to the substantia nigra. CBD’s effects didn’t depend on specific receptors like CB1 or TRPV1.
Findings
- CBD works mainly through its antioxidant properties.
- CBD targets specific brain cells connecting to the substantia nigra.
- CBD’s effects aren’t influenced by CB1 or TRPV1 receptors.
Does CBD Delay HD?
A similar study from the same university provides preclinical evidence supporting the neuroprotective effects of Sativex, a cannabis-based medicine, in delaying HD progression.
The study looked at whether combinations of botanical extracts with Δ(9)-tetrahydrocannabinol (Δ(9)-THC) or cannabidiol (CBD) could protect rats with Huntington’s disease (HD). Rats were given these extracts after being exposed to toxic chemicals.
Combining Δ(9)-THC and CBD extracts, similar to those in Sativex, helped reduce HD symptoms in rats. It protected brain cells, improved certain markers, and lowered inflammation. These effects were likely due to the antioxidants in both extracts and were not influenced by specific receptors.
Buy Weed Online – Indica-Dominant Strains With CBD
| Product | Effects | CBD Terpenes |
| Lemon Cherry Gelato | Happy Relaxing Uplifting | Myrcene Limonene Pinene |
| Gorilla Glue #4 | Euphoria Sedation Creativity | Caryophyllene Myrcene Humulene |
| Gelato Cake | Cerebral Euphoric Rush | Terpinolene Myrcene Pinene |
| Gas Tanker | Euphoria Calming Focus | Limonene Linalool Myrcene |
| Jealousy | Soothing Uplifting Relaxation | Myrcene Pinene Caryophyllene |
New Customers’ Go-To CBD and THC Online Buds Stop
To understand how CBD could help with Huntington’s Disease, you have to explore its effects and mechanisms. As you buy marijuana online and experiment with various cannabis products, clarify the effectiveness of CBD for the best cannabis experience.
With CBD products from GetLoud Cannabis gaining popularity, both new users and experienced cannabis users must stay informed. With a variety of best brands in stock, you can enjoy savings on prices and convenient delivery options.
Frequently Asked Questions
Does Indica always have CBD?
Indica strains tend to have higher CBD levels than Sativa strains, but it’s not guaranteed that all Indica strains will have significant CBD levels. The cannabinoid content, including CBD, can vary widely depending on factors such as genetics, growing conditions, and processing methods.
Some Indica strains may have higher THC levels and lower CBD levels, while others may have more balanced THC-to-CBD ratios.
Aside from weed strains, what other CBD products can I use for Huntington’s Disease?
- Oil/Tinctures. These are liquid extracts infused with CBD, which can be taken orally. They are commonly preferred for their ease of use and precise dosing.
- Capsules. These pre-measured capsules containing CBD oil offer a convenient way to consume CBD.
- Edibles. These include various food products infused with CBD, such as gummies, chocolates, and baked goods. They provide a discreet and tasty way to consume CBD.
- Topicals. Creams, lotions, balms, and salves infused with CBD can be applied directly to the skin over affected areas to alleviate pain and inflammation.
- Vape Products. CBD-infused vape oils or e-liquids can be vaporized and inhaled for fast-acting relief.
- Isolate. This pure form of CBD comes in crystalline or powder form and can be added to food, beverages, or homemade topical products.
- Patches. Transdermal patches infused with CBD slowly release the compound into the bloodstream over time for long-lasting relief.
How much CBD should an HD patient start with?
The appropriate dosage of CBD for an individual with HD can vary depending on the severity of symptoms, individual tolerance, and the specific CBD product being used.
A general recommendation is to start with a low dose of around 5-10 milligrams of CBD daily and gradually increase the dosage by 5-10 milligrams every few days until symptom relief is achieved. It’s important to track how the individual responds to different dosages and adjust accordingly.
It’s also advisable for HD patients to consult with a healthcare professional experienced in cannabinoid therapy to develop a personalized treatment plan tailored to their specific needs and medical history.